PANTERA
ProstAte cancer Novel ThERApy
A trial to investigate whether regular exercise can help keep prostate cancer from spreading to other parts of the body and could be a viable NHS treatment. It evaluated the feasibility of exercise therapy in men with localised prostate cancer, in terms of recruitment, adherence and compliance over 12 months of supervised exercise training.
Watch: Could exercise be a treatment for prostate cancer?
Video credit: Cancer Research UK
Project details
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ProstAte cancer Novel ThERApy
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Recruitment and follow-up complete.
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Cancer Research UK project grant.
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The aim of the study is to evaluate if exercise therapy in men with localised prostate cancer will be feasible in terms of recruitment rate and willingness of the participants to be randomized, intervention adherence, compliance to the exercise prescription, attrition due to the intervention, and reporting on secondary outcome standard deviations (variance in the data) to assist in sample size estimates for a larger-scale trial.
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Primary objectives of the feasibility study are:
to measure rate of recruitment to inform planning for a full-scale trial
to measure eligibility rate among those screened
to measure intervention adherence
to measure study completion rate
to measure adverse events
to measure the standard deviation of PSA to inform sample size planning for a full-scale trial.
Secondary objectives are to investigate:
if there is an impact on total exercise behaviour
if there is an impact on PSA
if there is an impact on serum androgen profile, lipid profile and HbA1c
if there is an impact resting heart rate, resting blood pressure and aerobic exercise tolerance
if there is an impact body weight
if there is an impact quality of life
if there is an impact dietary habits
if the trial/exercise intervention is delivered as intended
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Phase II feasibility RCT.
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12 months of supervised exercise training in men with low/intermediate risk prostate cancer is feasible and acceptable with a low progression rate to radical treatment. Early signals on clinically relevant markers were found which warrant further investigation.
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Professor Liam Bourke:
l.bourke@shu.ac.ukProfessor Derek Rosario:
derek.rosario@nhs.net -
Bourke L, Stevenson R, Turner R, Hooper R, Sasieni P, Greasley R, Morrissey D, Loosemore M, Fisher A, Payne H, Taylor SJC, Rosario DJ. Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study. Sci Rep. 2018 May 30;8(1):8374.